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"The Night Shift" focuses on the men and women who work the overnight shift at San Antonio Memorial Hospital. They are an irreverent and special breed, particularly adrenaline junkie T.C. Callahan. After three grueling tours of duty in Afghanistan, T.C. is about to learn that his toughest battles will be fought right here at home. He and his team of late-night docs, including best friend Topher and protégé Drew, know how to let off steam with the casual prank or two, but when lives are at stake, they are all business. Unfortunately, the night shift is now under new senior management and boss Michael Ragosa, who has to balance the real-world pressures of cutting costs while battling the stigma that he is more interested in saving money than helping people.

Season 3, Episode 1: The Times They Are A-Changin

The night shift crew is back for more action and the gang finds themselves immersed in a life-and-death rescue of a woman gravely injured in a car accident. While TC Callahan, Scott Clemmens and Topher Zia deal with the situation at the hospital, Drew Alister is serving time overseas in Afghanistan and he, along with colleague Syd Jennings, have to figure out a way around the cultural divide to treat a young Afghani woman. Jordan Alexander has recruited Shannon Rivera to the night shift team and the recent med school graduate is eager to prove herself, but her spunky, outspoken nature may not sit well with everyone, particularly Paul Cummings. TC's sister-in-law, Annie, returns and JR Lemon also stars as Nurse Kenny Fournette.