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DR. GREGORY HOUSE (Hugh Laurie) is devoid of bedside manner and wouldn't even talk to his patients if he could get away with it. Dealing with his own constant physical pain, he uses a cane that seems to punctuate his acerbic, brutally honest demeanor. While his behavior can border on antisocial, House is a maverick physician whose unconventional thinking and flawless instincts have afforded him a great deal of respect. An infectious disease specialist, he's a brilliant diagnostician who loves the challenges of the medical puzzles he must solve in order to save lives. House's roster of medical cases are the inexplicable ones other doctors can't solve, and he has assembled an elite team of young medical experts to help him in his effort to solve these diagnostic mysteries. House's team includes neurologist DR. ERIC FOREMAN (Omar Epps), who might have a slightly suspect past; immunologist DR. ALLISON CAMERON (Jennifer Morrison); and old-money intensevist DR. ROBERT CHASE (Jesse Spencer). House also has a good friend in DR. JAMES WILSON (Robert Sean Leonard), an oncology specialist with whom he consults on a regular basis.