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With a plague of comas seizing the world, John Constantine and his best friend Chas Chandler travel from the UK to Los Angeles to try to discern its origin. They unwittingly step into a war between gods, most notably Mictlantecuhtli, the Aztec deity of death, who resents Constantine's intrusion into his business. Beroul, a demon who behaves as if he were a Hollywood movie executive, holds hostage the soul of Chas' granddaughter Trish. Constantine can get her back, if he disposes of Beroul's enemies, which he eventually does by enlisting the help of Mictlantecuhtli. Constantine is able to trick his way out of the bargain, however. The story begins on a dark night in Liverpool in August 1961.