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The story is set in the 23rd century on a distant planet called New Texas, which is located 600 parsecs (=1956 light-years) from Earth and has "a sky of three suns." New Texas has a native population of "Prairie People," which are small beings who resemble prairie dogs (both Scuzz and Fuzz are members of this species), and has been colonized by a multi-planet government. A mineral called Kerium, a rare and powerful crystal of great importance in spacefaring societies said to be ten times more valuable than gold, is discovered there, giving the planet a valuable natural resource. Most of the episodes revolve around the heroes preventing the villains from stealing Kerium ore.

The culture of the New Texas colony (inhabited predominantly by humans but also by various aliens and robots) bears a remarkable resemblance to the culture of the American Old West. In addition to Kerium mining, the planet is also the site of "solacow" ranching. "Solacows" are large cattle-like creatures.

Two episodes are set on Earth, where the city of London resembles Victorian England, including a time travelling Sherlock Holmes. This lends a steampunk flavor to the series and is a logical extension of the series' setting.